東北大学 大学院農学研究科 応用生命科学専攻



これまでの業績  (1996〜2012)

 Katsuhiko NISHIMORI (prof.)
 
77 Mesic,I., Guzman,Y.F., Guedea,A.L., Jovasevic,V., Corcoran,K.A., Leaderbrand,K., Nishimori,K., Contractor,A., and Radulovic,J. 
Double Dissociation of the Roles of Metabotropic Glutamate Receptor 5 and Oxytocin Receptor in Discrete Social Behaviorsm.
Neuropsychopharmacology,(2014 in press)


76 Maejima,Y., Rita,R.S., Santoso,P., Aoyama,M., Hiraoka,Y., Nishimori,K., Gantulga,D., Shimomura,K., and Yada,T. 
Nasal Oxytocin Administration Reduces Food Intake without Affecting Locomotor Activity and Glycemia with c-Fos Induction in Limited Brain Areas.
Neuroendocrinology 101; 2699-708 (2014)


75 Katayama,M., Donai,K., Sakakibara,H., Ohtomo,Y., Miyagawa,M., Kuroda,K., Kodama,H., Suzuki,K., Kasai,N., Nishimori,K., Uchida,T., Watanabe,K., Aso, H., Isogai,E., Sone,H., and Fukuda,T. 
“Coffee consumption delays the hepatitis and suppresses the inflammation related gene expression in the Long-Evans Cinnamon rat.
Clin Nutr.33;302-10(2014)


74 Hattori,T., Kanno,K., Nagasawa,M., Nishimori,K., Mogi,K., and Kikusui,T. 
Impairment of interstrain social recognition during territorial aggressive behavior in oxytocin receptor-null mice.
Neurosci Res 90: 90-94(2014)


73 Maejima Y, Sakuma S, Santoso P, Gantulga D, Katsurada K, Ueta Y, Hiraoka Y, Nishimori K, Tanaka S, Shimomura K, Yada T. 
Oxytocinergic circuit from paraventricular and supraoptic nuclei to arcute POMC neurons.
FEBS Lett, 588;4404-12 (2014)


72 Ihara,K., Asanuma,K., Fukuda,T., Ohwada,S., Yoshida,M., and Nishimori,K. 
MAGI-2 is Critical for the Formation and Maintenance of the Glomerular Filtration Barrier in Mouse Kidney.
American Journal of Pathology, 184; 2699-708 (2014)


71 Kida,T., Oyama, K., Sone, M., Koizumi, M., Hidema, S., and Nishimori, K. 
Lgr4 is required for endometrial receptivity acquired through ovarian hormone signaling.
Bioscience, Biotechnology, and Biochemistry, 118 (2013)


70 Guzma´n,Y.F,, Tronson,N.C., Jovasevic,V., Sato,K., Ivana Mesic, Guedea,A.L., Nishimori,K. and Radulovic,J. 
Role of oxytocin receptors in modulation of fear by social memory.
Psychopharmacology, 231; 2097-2105 (2013)


69 Donai K, Kuroda K, Guo Y, So K-H, Sone H, Kobayashi M, Nishimori K and Fukuda T.  
Establishment of a Reporter System to Monitor Silencing Status in induced Pluripotent Stem Cell Lines.
Anal Biochem, 443;104-112 (2013)


68 Kasahara Y, Sato K, Takayanagi Y, Mizukami H, Ozawa K, Hidema S, So K-H, Kawada T, Inoue N, Ikeda I, Roh S-G, Itoi K, and Nishimori K. 
Oxytocin Receptor in the Hypothalamus Is Sufficient to Rescue Normal Thermoregulatory Function in Male Oxytocin Receptor Knockout Mice.
Endocrinology, 154:4305-4315 (2013)


67 Sone M, Oyama K, Mohri Y, Hayashi R, Clevers H and Nishimori K. 
LGR4 expressed in uterine epithelium is necessary for uterine gland development and contributes to decidualization in mice.
The FASEB Journal, 27:1-12 (2013)


66 Guzman,Y.F., Tronson,N.C., Jovasevic,V., Sato,K., Guedea,A.L., Mizukami,H., Nishimori,K., Radulovic,J. 
Fear-enhancing effects of septal oxytocin receptors.
Nat Neurosci, 118:1185−1187 (2013)


64 Mohri,Y., Oyama,K., Sone,M., Akamatsu,A., and Nishimori,K. 
LGR4 is required for the cell survival of the peripheral mesenchyme at the embryonic stages of nephrogenesis.
Biosci Biotechnol Biochem 76 : 888-91 (2012)

64 Sala,M., Braida,D., Donzelli,A., Martucci,R., Busnelli,M., Bulgheroni,E., Rubino,T., Parolaro,D., Nishimori,K. and Chini,B. 
Mice heterozygous for the oxytocin receptor gene (Oxtr(+/-) ) show impaired social behaviour but not increased aggression or cognitive inflexibility: evidence of a selective haploinsufficiency gene effect.
Journal of Neuroendocrinology 25: 107-118 (2013)


63 Fukuda T, Kurita J, Saito T, Yuasa K, Kurita M, Donai K, Nitto H, Soichi M, Nishimori K, Uchida T, Isogai E, Onuma M, Sone H, Oseko N, Inoue-Murayama M. 
Efficient establishment of primary fibroblast cultures from the hawksbill sea turtle (Eretmochelys imbricata).
In Vitro Cell Dev Biol Anim. 48: 660-5 (2013)

62 Yamashita,M., Takayanagi,Y., Yoshida,M., Nishimori,K., Kusama, M. and Onaka,T. 
Involvement of prolactin-releasing peptide in the activation of oxytocin neurones in response to food intake.
Journal of Neuroendocrinology. 25, 455-65 (2013)


61 Katayama,M., Donai,K, Sakakibara,H., Ohtomo,Y, Miyagawa,M., Kuroda,K., Kodama,H., Suzuki,K., Kasai,N., Nishimori,K., Uchida,T., Watanabe,K., Aso,H., Isogai,E., Sone,H. and Fukuda,T. 
Coffee consumption delays the hepatitis and suppresses the inflammation related gene expression in the Long-Evans Cinnamon rat.
Clin Nutr (2013)
(2013)

60 Tsuneoka,Y., Maruyama,T., Yoshida,S, Nishimori,K., Kato,T, Numan,M., Kuroda O.,K. 
Functional, anatomical, and neurochemical differentiation of medial preoptic area subregions in relation to maternal behavior in the mouse.
J Comp Neurol, 521,1633-63
(2013)

59 Colaianni G, Sun L, Benedetto A Di, Tamma R, Zhu LL, Cao J, Grano M, Yuen T, Colucci S, Cuscito C, Mancini M, Li J, Nishimori K, Bab I, Lee HJ, Iqbal J, Young WS, Rosen C, Zallone A, and Zaidi M. 
Bone marrow oxytocin mediates the anabolic action of estrogen on the skeleton.
J Biol Chem 287 : 29159-67 (2012)


58 Date,S., Nozawa,O., Inoue,H., Hidema,S. and Nishimori,K. 
Impairment of pachytene spermatogenesis in dmrt7 deficient mice, possibly causing meiotic arrest.s
Biosci Biotechnol Biochem 76 : 1621-1626 (2012)


57 Narahara H, Sakai E, Katayama M, Ohtomo Y, Yamamoto K, Takemoto M, Aso H, Ohwada S, Mohri Y, Nishimori K, Isogai E, Yamaguchi T, and Fukuda T. 
Immunological characteristics and response to lipopolysaccharide of mouse lines selectively bred with natural and acquired immunities.
Anim Sci J, 83 : 367-74 (2012)


56 Hidema, S., Tonomura,Y., Date,S. and Nishimori,K. 
Effects of protein transduction with intact myogenic transcription factors tagged with HIV-1 Tat-PTD (T-PTD) on myogenic differentiation of mouse primary cells
J Biosci Bioeng 113: 5-11(2012)


55 Ihara K, Nishimura T, Fukuda T, Ookura T, Nishimori K. 
Generation of Venus reporter knock-in mice revealed MAGI-2 expression patterns in adult mice
Gene Expression Patterns 12 :pp95-101 (2012) [Pub Med]


54 Mohri Y, Oyama K, Sone M, Akamatsu A, Nishimori K. 
LGR4 is required for the cell survival of the peripheral mesenchyme at embryonic stages of nephrogenesis
Bioscience, Biotechnology, and Biochemistry 240:1626-1634(2011)


53 Oyama K, Mohri Y, Sone M, Nawa A, Nishimori K.
Conditional Knockout of Lgr4 Leads to Impaired Ductal Elongation and Branching Morphogenesis in Mouse Mammary Glands
Sex Dev. 5: pp205-212 (2011) [Pub Med]


52 de Lau W, Barker N, Low TY, Koo BK, Li VS, Teunissen H, Kujala P, Haegebarth A, Peters PJ, van de Wetering M, Stange DE, van Es JE, Guardavaccaro D, Schasfoort RB, Mohri Y, Nishimori K, Mohammed S, Heck AJ, Clevers H.
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
Nature 476 : pp293-7 (2011) [Pub Med]


51 Mohri Y, Oyama K, Akamatsu A, Kato S, Nishimori K.
Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3
Developmental Dynamics 240:1626-1634 (2011) [Pub Med]


50 Wrobel L, Schorscher-Petcu A, Dupre A, Yoshida M, Nishimori K, Tribollet E.
Distribution andidentityofneuronsexpressingtheoxytocinreceptorinthe mouse spinalcord
Neuroscience Letters 495:49-54(2011)[Pub Med]


49 Sala M, Braida D, Lentini D, Busnelli M, Bulgheroni E, Capurro V, Finardi A, Donzelli A, Pattini L, Rubino T, Parolaro D, Nishimori K, Parenti M, Chini B.
Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: A neurobehavioral model of autism
Biol Psychiatry 69:875−882 (2011) [Pub Med]


48 Sinclair MS, Perea-Martinez I, Dvoryanchikov G, Yoshida M, Nishimori K, Roper SD, Chaudhari N.
Oxytocin Signaling in Mouse Taste Buds
PLoS ONE 5:e11980-11990 (2010) [Pub Med]

47 Mohri Y, Umezu T, Hidema S, Tomisawa H, Akamatsu A, Kato S, Nawa A, Nishimori K.
Reduced fertility with impairment of early-stage embryos observed in mice lacking Lgr4 in epithelial tissues.
Fertility and Sterility 45:2878-2881 (2010)
[Pub Med]

46 Schorscher-Petcu A, Sotocinal S, Ciura S, Dupre A, Ritchie J, Sorge RE, Crawley JN, Hu SB, Nishimori K, Young LJ, Tribollet E, Quirion R, Mogil JS.
Oxytocin-induced analgesia and scratching are mediated by the vasopressin-1A receptor in the mouse
Journal of Neuroscience 30: 8274-8284 (2010) [Pub Med]


45 Sato K, Date S, Aoyagi Y, Kasahara Y, Nawa A, Mizukami H, Hidema S, Ozawa K, Nishimori K.
Generation of Adeno-Assosiated Virus Vector Enabling Functional Expression of Oxytocin Receptor and Fluorescence Marker Genes Using the Human eIF4G Internal Ribosome Entry Site Element
Bioscience, Biotechnology, and Biochemistry 73, pp.2145-2148 (2009) [Pub Med]

44 Tabata C, Ogita K, Sato K, Nakamura H, Qing Z, Negoro H, Kumasawa K, Temma-Asano K, Tsutsui T, Nishimori K, Kimura T.
Calcineurin/NFAT Pathway: A Novel Regulator of Parturition.
Am J Reprod. Immunol. 62 pp.44-50 (2009) [Pub Med]

43 Sugimura S, Narita K, Yamashiro H, Sugawara A, Shoji T, Terashita Y, Nishimori K, Konno T, Yoshida M, Sato E.
Interspecies somatic cell nuclear transfer with porsine oocytes as resipients:A novel bioassay system for assessing the competence of canine somatic cells to develop into embryos.
Elsevir Editorial System(tm)for Theriogenology (2009) [Pub Med]

42 Tamma R, Colaianni G, Zhu LL, DiBenedetto A, Greco G, Montemurro G, Patano N, Strippoli M, Vergari R, Mancini L, Colucci S, Grano M, Faccio R, Liu X, Li J, Usmani S, Bachar M, Bab I, Nishimori K, Young LJ, Buettner C, Iqbal J, Sun L, Zaidi M, Zallone A.
Oxytocin is an anabolic bone hormone.
Proc.Natl.Acad.Sci.USA, 106, pp.7149-7154 (2009) [Pub Med]

41 Yoshida M, Takayanagi Y, Inoue K, Kimura T, Young LJ, Onaka T, Nishimori K.
Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice.
J.Neuroscience 29(7):2259-2271 (2009) [Pub Med]


40 Yoshida M, Takayanagi Y, Inoue K, Kimura T, Young LJ, Onaka T, Nishimori K.
Noninvasive Measurement of Fecal Progesterone Concentration in Toy Poodles by Time Resolved Fluoroimmunoassay (TR-FIA).
American Journal of Animal and Veterinary Sciences 3(1):43-46 (2008) [Pub Med]

39 Nishimori K, Takayanagi Y, Yoshida M, Kasahara Y, Young LJ, Kawamata M.
New aspects of oxytocin receptor function revealed by knockout mice: sociosexual behaviour and control of energy balance.
Prog. Brain Res. 170: 79-90 (2008) [Pub Med]

38 Mohri Y, Kato S, Umezawa A, Okuyama R, Nishimori K
Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4.
Dev.Dynamics 237:2235-2242 (2008)
[Pub Med]

37 Takayanagi Y, Kasahara Y, Onaka T, Takahashi N, Kawada T, Nishimori K.
Oxytocin receptor-deficient mice developed late-onset obesity.
Neuroreport 19, 951-955 (2008) [Pub Med]

36 Kawamata M, Yoshida M, Sugimoto Y, Kimura T, Tonomura Y, Takayanagi Y, Yanagisawa T, Nishimori K.
Infusion of oxytocin induces successful delivery in prostanoid FP-receptor-deficient mic.
Mol.Cell Endocrinol. 283: 32-37 (2008) [Pub Med]


35 Kasahara Y, Takayanagi Y, Kawada T, Itoi K, Nishimori K.
Impaired Thermoregulatory Ability of Oxytocin-deficient Mice during Cold- exposure.
Biosci.Biotechnol. Biochem. 71, 3122-3126 (2007) [Pub Med]

34 Kawamata M, Inoue H, Nishimori K.
Male-specific function of Dmrt7 by sexually dimorphic translation in mouse testis.
Sexual Development 1, 297-304 (2007) [Pub Med]

33 Kato S, Mohri Y, Matsuo T, Ogawa E, Umezawa A, Okuyama R, Nishimori K.
Eye-open at birth phenotype with reduced keratinocyte motility in LGR4 null mice.
FEBS Letter 581, 4685-4690 (2007) [Pub Med]

32 Hidema S, Maruyama T, Kato S, Nishimori K.
Highly Induced DNA Recombination Mediated by Membrane Permeabilized Recombinant Cre Protein in Mouse Primary Cells.
Biosci Biotechnol Biochem. 71, 817-820 (2007) [Pub Med]


31 Maruyama T, Hatakeyama S, Miwa T, Nishimori K.
Human Smooth Muscle a-Actin Promoter Drives Cre Recombinase Expression in Cranial Suture in Addit ion to Smooth Muscle Cells.
Biosci Biotechnol Biochem. 71, 1103-1106, (2007) [Pub Med]


30 Kawamata M, Tonomura Y, Kimura T, Yanagisawa T, Nishimori K.
Oxytocin-induced phasic and tonic contractions are modulated by the contractile machinery rather than the quantity of oxytocin receptor.
Am. J. Physiol.292, E992-E999, (2007) [Pub Med]

29 Tanino T, Nawa A, Kondo E, Kikkawa F, Daikoku T, Tsurumi T, Luo C, Nishiyama Y, Takayanagi Y, Nishimori K, Ichida S, Wada T, Miki Y, Iwaki M.
Paclitaxel-2'-Ethylcarbonate Prodrug Can Circumvent P- glycoprotein-mediated Cellular Efflux to Increase Drug Cytotoxicity.
Pharm Res : (2007) [Pub Med]


28 Kawamata M, Nishimori K.
Mice deficient in Dmrt7 show infertility with spermatogenic arrest at pachytene stage.
FEBS Letter 580, 6422-6446 (2006) [Pub Med]

27 Kato S, Matsubara M, Matsuo T, Mohri Y, Kazama I, Hatano R, Umezawa A, Nishimori K.
Leucine-rich repeat-containing G protein-coupled receptor-4 (LGR4, Gpr48) is essential for renal development in mice.
Nephron Exp Nephrol ;104:e63-e75 (2006) [Pub Med]

26 Takayanagi Y, Yoshida M, Bielsky IF, Ross HE, Kawamata M, Onaka T, Yanagisawa T, Kimura T, Matzuk MM, Young LJ, Nishimori K.
Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice.
Proc Natl Acad Sci USA 102: 16096-16101 (2005) [Pub Med]


25 Takayanagi Y, Nishimori K, Onaka T.
Salt loading reduces hypothalamic noradrenaline release after noxious stimuli.
Neuroscience Letters 391:22-27 (2005) [Pub Med]


24 Kawamata M, Tonomura Y, Kimura T, Yanagisawa T, Nishimori K.
The differential coupling of oxytocin receptors to uterine contractions in murine estrous cycle.
Biochem. and Biophys.Res.Commu.321, 695-699 (2004) [Pub Med]

23 Kimura T, Saji F, Nishimori K, Ogita K, Nakamura H, Koyama M, Murata Y.
Molecular regulation of the oxytocin receptor in peripheral organs.
J Mol. Endocrinol. 30: 109-115, (2003) [Pub Med]

22 Nicolson GL, Nawa A, Toh Y, Taniguchi S, Nishimori K, Moustafa A.
Tumor metastasis-associated human MTA1 gene and its MTA1 protein product: role in epithelial cancer cell invasion, proliferation and nuclear regulation.
Clin Exp Metastasis 20: 19-24 (2003) [Pub Med]

21 Kawamata M, Mitsui-Saito M, Kimura T, Takayanagi Y, Yanagisawa T, Nishimori K.
Vasopressin-induced contraction of uterus is mediated solely by the oxytocin receptor in mice, but not in humans.
Eur J.Pharmacol. 472:229-234, (2003) [Pub Med]

20 Oma Y, Nishimori K, Harata M.
The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP,
Biochem Biophys Res Commun 301: 521-528 (2003) [Pub Med]


19 Kuroda Y, Oma Y Nishimori K, Ohta T, Harata M.
Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex.
Biochem Biophys Res Commun 299: 328-334 (2002) [Pub Med]


18 Ohfuchi E, Nishimori K, Harata M.
Alternative splicing products of the gene for a human nuclear actin-related protein, hArpNbeta/Baf53, that encode a protein isoform, hArpNbetaS, in the cytoplasm.
Biosci Biotechnol Biochem 66: 1740-1743 (2002) [Pub Med]


17 Furuhashi M, Suganuma N, Nishimori K.
Successful pregnancy in a patient having high basal serum levels of sex steroid hormones.
Arch Gynecol Obstet 267: 46-48(2002) [Pub Med]

16 Harata M, Zhang Y, Stillman DJ, Matsui D, Oma Y, Nishimori K, Mochizuki R.
Correlation between chromatin association and transcriptional regulation for the Act3p/Arp4 nuclear actin-related protein of Saccharomyces cerevisiae.
Nucleic Acids Res 30: 1743-1750, (2002) [Pub Med]


15 Nawa A, Obata N, Kikkawa F, Kawai M, Nagasaka T, Goto S, Nishimori K, Nakashima N.
Prognostic factors of patients with yolk sac tumors of the ovary.
Am J Obstet Gynecol 184: 1182-1188 (2001) [Pub Med]


14 Yotsu-Yamashita M, Nishimori K, Nitanai Y, Isemura M, Sugimoto A, Yasumoto T.
Binding properties of 3H-PbTx-3 and 3H-saxitocin to brain membranes and to skeltal muscle membranes of puffer fish Fugu paradalis and the primary structure of a voltage-gated Na+ channel a-subunit (fMNa1) from the skeletal muscle of F.pardalis.
Biochem. Biophys. Res. Commun., 267, pp.403-412 (2000) [Pub Med]


13 Nawa A, Nishimori K, Lin P, Maki Y, Moue K, Sawada H, Toh Y, Fumitaka K, Nicolson GL.
Tumor metastasis-associated human MTA1 gene: its sequence analysis and association with cancer cell proliferation.
Cell Biochem., 79 , pp.202-212 (2000) [Pub Med]

12 Lau AL, Kumar TR, Nishimori K, Bonadio J, Matzuk MM.
Activin bC and activin bE genes are not essential for mouse liver growth, differentiation, and regeneration.
Mol. Cell Biol., 20 , pp.6127-6137 (2000) [Pub Med]

11 Nawa A, Sawada H, Toh Y, Nishimori K, Nicolson GL.
Tumor metastasis- associated human MTA1 gene: effects of antisense oligonucleotides on cell growth.
Intern. J. Med. Biol. Environ., 28 , pp.33-39 (2000)


10 Wajima Y, Furusawa T, Kawauchi S, Wakabayashi N, Nakabayashi O, Nishimori K, Mizuno S.
The cDNA cloning and transient expression of an ovary-specific 17beta-hydroxysteroid dehydrogenase of chickens.
Gene, 233 , pp.75-82 (1999) [Pub Med]


09 Elvin JA, Yan C, Wang P, Nishimori K, Matzuk MM.
Molecular characterization of (the follicle defects in) the growth differentiation factor 9-deficient ovary.
Mol. Endocrinol., 13 , pp.1018-1034 (1999) [Pub Med]


08 Nomura O, Nakabayashi O, Nishimori K, Yasue H, Mizuno S.
Expression of five steroidogenic genes including aromatase gene at early developmental stage of chicken male and female embryos.
J. Steroid Biochem. Mol. Biol., 71 , pp.103-109 (1999) [Pub Med]


07 Nomura O, Nishimori K, Nakabayashi O, Yasue H, Mizuno S.
Determination by modified RT-PCR of transcript amounts from genes involved in sex-steroid synthesis in chicken organs including brain.
J. Steroid. Biochem. Mol. Biol. 67 , pp.143-148 (1998) [Pub Med]

06 Nomura O, Nakabayashi O, Nishimori K, Mizuno S.
The cDNA cloning and transient expression of a gene encoding cytochrome P-450scc.
Gene, 185, pp.217-222 (1997) [Pub Med]


05 Wakabayashi N, Suzuki A, Hoshino H, Nishimori K, Mizuno S.
The cDNA cloning and transient expression of a chicken gene encoding a follicle-stimulating hormone receptor.
Gene, 197 , pp.121-127 (1997) [Pub Med]


04 Lau AL, Nishimori K, Matzuk MM.
Structural analysis of the mouse activin beta C gene.
Biochim. Biophys. Acta, Gene Struct. Expr., 1307 , pp.145-148 (1996) [Pub Med]


03 Nishimori K, Matzuk MM.
Transgenic mice in the analysis of reproductive development and function.
Rev. Reprod., 1 , pp.203-212 (1996) [Pub Med]


02 Dong J, Albertini DF, Nishimori K, Kumar TR, Lu N, Matzuk MM.
Growth differentiation factor-9 is required during early ovarian folliculogenesis.
Nature, 382 , pp.531-535 (1996) [Pub Med]


01 Nishimori K, Young LJ, Guo Q, Wang Z, Insel TR, Matzuk MM.
Oxytocin is required for nursing but is not essential for parturition or reproductive behavior.
Proc. Natl. Acad. Sci. U.S.A., 93, pp.11699-11704 (1996) [Pub Med]

    
著書 (英文)

Nicolson, G. L. , Nawa, A. , Toh, Y. , Taniguchi, S. , and Nishimori, K. , "Tumor metastasis-associated human MTA1 gene : Role in epithelial cancer cell proliferation and regulation." in Metastasis-Associated Genes (D.Welch, Ed., Kluwer Publishers), pp.115-121 (2001)



総説・解説

1)西森克彦,吉田匡秀,笠原好之,高柳友紀 特集、神経ペプチド「オキシトシンと情動」分子精神医  学 VOL.8 pp.221-229(2008)

2)西森克彦,高柳友紀,吉田匡秀,笠原好之「オキシトシン受容体遺伝子の生理機能:本能行動制御から 体恒常性維持まで」化学と生物 Vol.45、 pp.826-833、(2007)

3)西森克彦 ,川又理樹,高柳友紀,「遺伝子欠損マウスによるオキシトシン・オキシトシン受容体システム の機能解析」,日本農芸化学会誌, 76,pp.30-33、(2002)

4)西森克彦,加藤成樹,川又理樹,高柳友紀「遺伝子欠損マウスが語る生殖関連GPCRの生体機能解析」 臨床化学33、154-162、(2004)


5)西森克彦 1998.「生殖に関連したTGF-bスーパーファミリィーメンバー」,蛋白質核酸酵素 43,  pp.491-501

6)西森克彦 1997.「動物の生殖を制御する遺伝子:ノックアウトテクノロジーによる新しい展開」,化学と 生物 35,pp.699-708

7)西森克彦 1993.「チトクロームP-450c17:リアーゼ活性のみを失ったニワトリP-450c17」,BIOmedica  8,pp.676-682

8)西森克彦 1989.「哺乳動物細胞のプラスミドベクター」,in細胞工学的技術総集編, 実験医学 7、pp.1582-1586

9)西森克彦 1988.「動物細胞のベクター系および動物細胞への遺伝子導入法(1)」in遺伝子工学実験講座, RADIOISOTOPES, 373, 645-657

10)西森克彦 1988.「動物細胞のベクター系および動物細胞への遺伝子導入法(2)」in遺伝子工学実験 講座, RADIOISOTOPES, 373, 645-657

11)総説「ウシプロキモシン遺伝子のクローン化と微生物における形質発現に関する研究」 1986,西森 克彦、Nippon Nogeikagaku Kaishi, 60, pp.119-127

12)「動物細胞における宿主ベクター系の現状と将来展望」1984,組織培養, 10, pp.294-301

13)「先端技術戦略調査研究会バイオテクノロジー?プロジェクト」?.動物細胞培養による有用物質生産「 ヒトまたは動物細胞由来生理活性物質の動物細胞以外の生産系による生産」pp.3-16,(1984),社団法 人日本能率協会編

14)「動物細胞利用実用化マニュアル」第7部「動物細胞のベクター系」西森克彦、pp388-400,(1984),リ アライズ社刊



ジャーナルeditorなど

○平成13年4月?平成17年3月、雑誌「化学と生物」(学会センター発行・日本農芸化学会編集)編集委員4年、2期

○Bioscience, Biotechnology and Biochemistry編集委員、平成17年4月より





 Masahiko HARATA (准教授)

25 Sun J, Oma Y, Harata M, Kono K, Shima H, Kinomura A, Ikura T, Mizutani S, Kanaarm R, Tashiro S.
ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot.
PLoS One 5, e13554 (2010)


24 Philimonenko VV, Janacek J, Harata M, Hozak P.
Transcription-dependent rearrangements of actin and nuclear myosin I in the nucleolus.
Histochem. Cell Biol. 134, 243-249 (2010)


23 Yoshida Y, Shimada K, Oma Y, Kalck V, Akimura K, Taddei A, Iwahashi H, Kugou K, Ohta K, Gasser SM, Harata M.
Actin-related protein Arp6 influences H2AZ-dependent and -independent gene expression and links ribosomal protein genes to nuclear pores.
PLoS Genet., 6, e1000910 (2010)

22 Matsuda R, Hori T, Kitamura H, Takeuchi K, Fukagawa T, Harata M.
Identification and characterization of two isoforms of the vertebrate H2A.Z histone variant.
Nucleic Acids Res., 38, 4263-4673 (2010)


21 Kumeta M., Yoshimura SH, Harata M, Takeyasu K.
Molecular mechanisms underlying nucleocytoplasmic shuttling of actinin-4.
J. Cell Sci. 123, 1020-1030 (2010)


20 Kitayama K, Kamo M, Oma Y, Matsuda R, Uchida T, Ikura T, Tashiro S, Ohyama T, Winsor B, Harata M.
The human actin-related protein hArp5: nucleo-cytoplasmic shuttling and involvement in DNA repair.
Exp Cell Res, 315, 206-217 (2009)


19 Shimada K, Oma Y, Schleker T, Kugou K, Ohta K, Harata M*, Gasser SM*.
(*corresponding authors)
Ino80 Chromatin Remodeling Complex Promotes Recovery of Stalled Replication Forks.
Curr Biol. 18, 566-575 (2008)

18 Miloshev J, Harata M, and Georgieva M
The nuclear actin-related protein Act3p/Arp4 influences yeast cell
shape and bulk chromatin organization

J Cell Biochem. 104, 59-67 (2008)


17 Aoyama N, Oka A, Kitayama K, Kurumizaka H, Harata M.
The actin-related protein hArp8 accumulates on the mitotic chromosomes and functions in chromosome alignment.
Exp Cell Res. 314, 859-868 (2008)


16 Kawashima S, Ogiwara H, Tada S, Harata M, Wintersberger U, Enomoto T, Seki M.
The INO80 complex is required for damage-induced recombination.
Biochem Biophys Res Commun, 355, 835-841 (2007)

15 Ogiwara H, Ui A, Kawashima S, Kugou K, Onoda F, Iwahashi H, Harata M, Ohta K, Enomoto T, Seki M.
Actin-related protein Arp4 functions in kinetochore assembly.
Nucleic Acids Res. 35, 3109-3117 (2007)


14 Ohfuchi, E., Kato, M., Sasaki, M., Sugimoto, K., Oma, Y., and Harata, M
Vertebrate Arp6, a novel nuclear actin-related protein, interacts with heterochromatin protein 1 Eur.
J. Cell Biol. 85, 411-421 (2006)


13 Sunada R, Goerzer I, Oma Y, Yoshida T, Suka N, Wintersberger U, and Harata M
The nuclear actin-related protein Act3p/Arp4p is involved in the dynamics of chromatin modulating.
complexes Yeast 22, 753-768 (2005)


12 Ueno, M., Murase T., Kibe, T., Ohashi, N., Tomita, K., Murakami, Y., Uritani, M., Ushimaru, T. and Harata, M.
Fission yeast Arp6 is required for telomere silencing but functions independently of Swi6.
Nucleic Acids Res. 32, 736-741 (2004)


11 Oma, Y., Nishimori, K., and Harata, M.
The brain-specific actin-related protein ArpNa interacts with the transcriptional co-repressor CtBP
Biochem. Biophys. Res. Commun. 301, 521-528 (2003)


10 Kuroda, Y., Oma, Y., Nishimori, K., Ohta, T., and Harata, M.
Brain-specific expression of the nuclear actin-related protein ArpNa and its involvement in mammalian SWI/SNF chromatin remodeling complex.

Biochem. Biophys. Res. Commun. 299, 328-334 (2002)


09 Harata, M., Zhang, Y., Stillman, D. J., Matsui, D., Oma, Y., Nishimori, K., and Mochizuki, R.
Correlation between chromatin association and transcriptional regulation for the Act3p/Arp4 nuclear actin-related protein of Saccharomyces cerevisiae.
Nucleic Acids Res. 30, 1743-1750 (2002)


08 Ohfuchi, E., Nishimori, K., and Harata, M.
Alternative splicing products of the gene for a human nuclear actin-related protein, hArpNb/Baf53, encode a protein isoform, hArpNbS, localized in the cytoplasm.
Biosci. Biotechnol. Biochem. 66, 1740-1743 (2002)
07 Harata, M., Nishimori, K., and Hatta, S.
Identification of two cDNAs for human actin-related proteins (Arps) that have remarkable similarity to conventional actin.
Biochim. Biophys. Acta. 1522, 130-133 (2001)


06 Kato, M., Sasaki, S., Mizuno, S., and Harata, M.
Novel actin-related proteins in vertebrates: similarities of structure and expression pattern to Arp6 localized on Drosophila heterochromatin.
Gene 268, 133-140 (2001)
05 Harata, M., Oma, Y., Tabuchi, T., Zhang, Y., Stillman, D. J., and Mizuno S.
Multiple actin-related proteins of Saccharomyces cerevisiae are present in the nucleus.
J. Biochem. 128, 665-671 (2000)


04 Harata, M., Oma, Y., Mizuno, S., Jiang, Y. W., Stillman, D. J., and Wintersberger, U.
The nuclear actin-related protein of Saccharomyces cerevisiae, Act3p/Arp4, interacts with core histones.
Mol. Biol. Cell 10, 2595-2605 (1999)


03 Harata, M., Mochizuki, R., and Mizuno, S.
Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues.
Biosci. Biotechnol. Biochem. 63, 917-923 (1999)


02 Weber, V., Harata, M., Hauser, H and Wintersberger, U.
The actin-related protein Act3p of Saccharomyces cerevisiae is located in the nucleus.
Mol. Biol. Cell, 6, 1263-1270 (1995)


01 Harata, M., Karwan, A. and Wintersberger, U.
A new essential gene of Saccharomyces cerevisiae coding for an actin-related protein.
Proc. Natl. Acad. Sci. U.S.A., 91, 8258-8262 (1994)



英語の総説
Oma, Y. and Harata, M.
Actin-related proteins localized in the nucleus: from discovery to novel roles in nuclear organization.
Nucleus 2, 38-46 (2011)

Harata M.
Involvement of the actin-related protein Arp6 in spatial organization of radial chromosome territories
Chromosome Science 11, 27 (2008)

Harata M., Ohfuchi E., Oma Y
“Nulcear actin-related proteins involved in the organization of euchromatin and heterochromatin” in DNA structure, chromatin, and gene expression eds. Shimizu M and Kiyama R. 181-191 (2006)

Harata M.
“Actin-related proteins involved in nuclear and chromatin dynamics” In: Nagata, S. and Takeyasu, K. (ed) Nuclear Dynamics: Approaches from Biochemistry, Molecular Cell Biology, and Visual Biology, Springer-Verlag Tokyo, Inc., Tokyo (2006)





最近の日本語の総説

細胞核におけるアクチンファミリーの多様な機能」
原田昌彦 蛋白質 核酸 酵素 49, 543-552 (2004)

「クロマチン構造変換複合体によるゲノム機能の制御:アクチン関連タンパク質(Arp)からのアプローチ」
原田昌彦、吉田貴人、大渕恵理 日本農芸化学会誌 78, 652-655 (2004)

「核内アクチンファミリーの分子機能」
原田昌彦、尾間由佳子
竹安邦夫、米田悦啓(編)細胞核のダイナミクス シュプリンガー・フェアラーク東京 pp177-186 (2004)

「クロマチンレベルの転写制御機構」
原田昌彦
細胞核の分子生物学 水野重樹(編) 朝倉書店 (2005)

「核の構造とその分子基盤」
原田昌彦、北山久美子、尾間由佳子 蛋白質核酸酵素 51, 591-599 (2006)

「クロマチン」
 原田昌彦 蛋白質核酸酵素 51, 1943-1949 (2006)


「クロマチン・細胞核の機能ドメイン形成」
尾間由佳子、松田涼、北村大志、原田昌彦  実験医学 27, 2752-2758 (2009)






最近の著書

細胞核−遺伝情報制御と疾患 
平岡泰、原田昌彦、木村宏、田代聡 編集
実験医学増刊、羊土社 (2009)